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WYC-209可抑制恶性小鼠黑色素瘤肿瘤再生细胞增殖，SPR分析通过美迪西使用Biacore 8K设备进行

2023-06-28
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Developing novel drugs that can abrogate the growth and metastasis of malignant tumors is a major challenge for cancer researchers. WYC-209, a synthetic retinoid, inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs). The enantiomers WYC-209A and WYC-209B exhibit similar TRC inhibition activities. The binding assay by surface plasmon resonance (SPR) analysis shows that WYC-209A and WYC-209B acid bind to RARs at nano-molar doses. SPR was carried out by Medicilon, using the Biacore 8K equipment.

Reference

Junwei Chen, et al. Inhibition of cancer stem cell like cells by a synthetic retinoid. Nat Commun. 2018 Apr 11;9(1):1406. doi: 10.1038/s41467-018-03877-7.

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